The Powder River Train Station was constructed in 1910 by employees of the Chicago and Northwestern (C&NW) Railroad in the small rural community of Powder River. The Station is representative of the primary influence of the C&NW in the settlement of central Wyoming. It was the first railroad in the area and provided accessible shipping points for a new and growing sheep industry, induced homesteaders to settle along its line, brought new towns to central Wyoming, and carried goods to the growing settlements at its stations. The Powder River Station was the focal point of commerce in Powder River and served as the post office and telegraph office as well as the passenger and freight depot.