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The Cheyenne VA Hospital Historic District, currently known as the Cheyenne Veterans Affairs Medical Center, is significant for its association with the federal government’s commitment to the health care of World War I and World War II veterans. Construction for the Cheyenne VA Hospital began in 1932, and the hospital opened in 1934. Construction of additional buildings and structures continued within the historic district throughout the latter half of the twentieth century. The Cheyenne VA Hospital Historic District was originally designated a general medical and surgical hospital serving veterans of southeastern Wyoming, northern Colorado and western Nebraska. The historic district continues to retain a campus setting with a monumental main building, and the hierarchal use of architectural decorative elements on the exteriors of the buildings creating a cohesive architectural district.